

iTunes backup is occasionally grayed out on Windows 10 for iPhone users who wish to back up their devices. You cannot back up your personal information from your device to iTunes backups. Have you ever wanted to back up your iPhone using iTunes on your PC only to discover that the Apple iTunes "Back Up Now" is grayed out? Do not worry as you are not the first one to be experiencing this phenomena / problem and probably won’t be the last as this problem has been the same since a few years with the iPhone models. Part 2: 5 Ways to Fix iCloud Backup Greyed Out Connecting to a stable internet connection should fix the problem. Weak Internet Connection: Sometimes, the users have a weak internet connection, which brings out the Back up now being greyed out the problem.Having an older version of the software can also cause this issue.
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iOS isn't Updated: Like the first point, iOS users generally do not update their software.Wrong Port or USB Cable: Another common reason for such an issue is that users connect their iPhone using the wrong port or an incompatible USB wire/cable.

One of the reasons you're getting this particular issue is that it might be because of your outdated iTunes application, which isn't letting you sync with your phone.

The iTunes shows the Back up now option is greyed out. There are times when you connect your iPhone through iTunes to the PC. Part 1: Why is manual backup greyed out in iTunes? Part 3: Restoring iPhone contacts with iTunes Backup
